Dr. Quake’s interests lie at the nexus of physics, biology and biotechnology. His group pioneered the development of Microfluidic Large Scale Integration (mLSI), demonstrating the first integrated microfluidic devices with thousands of mechanical valves. This technology is helping to pave the way for large scale automation of biology at the nanoliter scale, and he and his students have been exploring applications of “lab on a chip” technology in functional genomics, genetic analysis, and structural biology. Quake is also active in the field of single molecule biophysics; in 2003 his group demonstrated the first successful single molecule DNA sequencing experiments.