Rasmus Fonseca, PhD
"An integrative study of the activation mechanism of heterotrimeric protein Gs complexes"
Ninna Struck Rossen, PhD
"Engineering a tissue-mimicking platform to assess cancer metastasis therapy in vivo"
Tue Herlau, PhD
"Reliable inference of dynamical brain networks from multi-subject fMRI data"
Imaging fluorescently-labeled DNA in live cells with nanoscale precision shows significant promise as a diagnostic tool; however, the intrinsically stochastic nature of biological systems limits our ability to interpret meaningful signals from the noise. Here we discuss the implementation of advanced, 3D microscopy into an imaging flow cytometer and the unique calibration protocol we developed, in which we rely on statistical distributions rather than the unattainable static ground-truth. We demonstrate our system on live yeast cells, attaining 3D spatial information with orders of magnitude higher throughput than previous methods.
Tony Wyss-Coray
Jamshid Ghajar
Thomas Südhof
Euan Ashley
Ash Alizadeh
Melanie Hayden Gephart
Rajat Rohatgi
Seung Kim
Scott Dixon
JENNIFER ZALLEN, MEMORIAL SLOAN KETTERING CANCER CENTER
The Zallen lab is using molecular, genetic, and cell biological approaches to understand the machinery that directs morphogenetic events. An understanding of the cell rearrangements that occur during normal embryonic development will uncover general principles that build tissues and organs and can provide insight into how deranged versions of these processes contribute to human disease.
PAUL NURSE, THE FRANCIS CRICK INSTITUTE
The goals of Dr. Nurse's laboratory are to better understand the global cellular networks which regulate the eukaryotic cell cycle, cell form and cell growth. These cellular controls are fundamental to the growth, development and reproduction of all living organisms.
The Gartner lab seeks to answer questions about how tissue structure forms and functions. They take a synthetic approach, building human tissues from the bottom-up, which allows them to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behaviors.
The Weissman laboratory is looking at how cells ensure that proteins fold into their correct shape, as well as the role of protein misfolding in disease and normal physiology. They are also developing experimental and analytical approaches for exploring the organizational principles of biological systems and globally monitoring protein translation through ribosome profiling.
BRUCE EDGAR, UNIVERSITY OF UTAH
The Edgar lab uses genetics to characterize the programs of cell growth and proliferation that occur during development, regeneration and tumorigenesis, with the goal of finding the genes that act as limiting regulators in each context.
