SYLVAINE CASES, JOHNSON & JOHNSON INNOVATION
Dr. Cases's is the Vice President of Oncology Scientific Innovation at Johnson & Johnson Innovation in California. She has significant experience in the fields of cancer biology and metabolism, with more than 16 years in research and drug discovery in both pharma and biotech.
BOZHI TIAN, UNIVERSITY OF CHICAGO
Recent studies have demonstrated that in addition to biochemical and genetic interactions, cellular systems also respond to biophysical cues, such as electrical, thermal, and mechanical signals. However, we only have limited tools that can introduce localized physical stimuli and/or sense cellular responses with high spatiotemporal resolution. Dr. Tian's group integrates material science with biophysics to study several semiconductor-based biointerfaces.
BIANXIAO CUI, DEPARTMENT OF CHEMISTRY
Attend Dr. Cui's pre-seminar presentation to learn more about Dr. Bozhi Tian's seminar, "Physical biology at the semiconductor-enabled biointerfaces", to be held Thursday, October 4th.
Jonathan Pollack
Carolyn Bertozzi
Shirit Einav
Rasmus Fonseca, PhD
"An integrative study of the activation mechanism of heterotrimeric protein Gs complexes"
Ninna Struck Rossen, PhD
"Engineering a tissue-mimicking platform to assess cancer metastasis therapy in vivo"
Tue Herlau, PhD
"Reliable inference of dynamical brain networks from multi-subject fMRI data"
Imaging fluorescently-labeled DNA in live cells with nanoscale precision shows significant promise as a diagnostic tool; however, the intrinsically stochastic nature of biological systems limits our ability to interpret meaningful signals from the noise. Here we discuss the implementation of advanced, 3D microscopy into an imaging flow cytometer and the unique calibration protocol we developed, in which we rely on statistical distributions rather than the unattainable static ground-truth. We demonstrate our system on live yeast cells, attaining 3D spatial information with orders of magnitude higher throughput than previous methods.
Tony Wyss-Coray
Jamshid Ghajar
Thomas Südhof
Euan Ashley
Ash Alizadeh
Melanie Hayden Gephart
Rajat Rohatgi
Seung Kim
Scott Dixon
JENNIFER ZALLEN, MEMORIAL SLOAN KETTERING CANCER CENTER
The Zallen lab is using molecular, genetic, and cell biological approaches to understand the machinery that directs morphogenetic events. An understanding of the cell rearrangements that occur during normal embryonic development will uncover general principles that build tissues and organs and can provide insight into how deranged versions of these processes contribute to human disease.
