Dr. Dean Felsher's laboratory studies how oncogenes such as MYC initiate and maintain cancer. In particular we have shown that shutting down oncogenes even for a brief time can reverse cancer or elicit "Oncogene Addiction". For a recent review of their work, please see: The MYC oncogene - the grand orchestrator of cancer growth and immune evasion Nature Reviews Clinical Oncology, 2022

Examples of project in Dr. Felsher's laboratory include:

• They are studying basic mechanisms of Oncogene Addiction: the role of Self-renewal/Stemness, Metabolism, Host Immune System, Protein Biogenesis, Microbiome, Extracellular Vesicles
• They are developing novel therapeutics using small molecules, nanoparticles, proteins/peptides that can be used to target oncogenes and/or restore the immune response against cancer
• They are developing new diagnostic and imaging methods such as PET, Mass Spec, Nanoproteomics