Glutamate transporters are responsible for clearance of the neurotransmitter glutamate from the synaptic cleft following rounds of neurotransmission. They maintain steep concentration gradients of glutamate by coupling its uptake to symport of sodium ions and protons and to antiport of potassium ions. Dr. Boudker's lab has been investigating the molecular mechanism of this family of transporters.
Dr. Tycko will describe the highlights of his lab’s studies of amyloid structures, beginning with investigations of β-sheet organization in fibrils formed in vitro and culminating in structural studies of fibrils derived from AD brain tissue.
The regulation of information flow by local inhibitory microcircuits has a fundamental role in shaping animal behavior. In the mammalian spinal cord GABAergic inhibitory interneurons serve key functions in sensory-motor transformation.
Dr. Hubbell's group is particularly interested in therapeutic vaccination in cancer, and they have determined that the tumor-draining lymph node is a particularly opportune lymphoid target for cancer vaccination.
Dr. Ren will present recent findings related to 3D genome organization in mammalian cells, with a particular focus on how chromatin organization contribute to enhancer-mediated transcriptional regulation.