Projects in Dr. Baumeister's group include using Cryo-Electron Tomography, exploring phase contrast methods, understanding the 26S proteasome, studying the structural mechanisms of neuodegenerative disease, studying the structural mechanisms of visual proteomics, studying tripeptidyl peptidase II, studying the 70S ribosome, examining membrane and cell wall proteins, and studying synaptic complexes.
The You lab's research is at the nexus of biology, engineering, and medicine. They combine mathematical modeling and experiments to analyze dynamics of cell signaling processes, including cell cycle regulation, bacterial response to antibiotics, and cell-cell communication.
Dr. Wang’s group has developed highly sensitive, quantitative and clinically relevant technologies for analysis of genomic markers based on the convergence of SMS, microfluidic manipulations, and quantum dots.
“Mice are not little people” – a refrain becoming louder as the strengths and weaknesses of animal models of human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell and intracellular signaling networks in patient-derived samples; 3D tissue engineered models of human organ systems, often made from stem cells; and micro-fluidic and meso-fluidic devices that enable living systems to be sustained, perturbed and analyzed for weeks in culture. This talk will highlight the integration of these rapidly moving fields to understand difficult clinical problems, with an emphasis on translating academic discoveries into practical, widespread use.
The connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology.
Over the past decade, Dr. Schaffer's group initially developed and has been implementing directed vector evolution as a high throughput approach to engineer adeno-associated virus (AAV) variants with novel properties, including enhanced biodistribution and spread, targeted delivery to specific cells such as stem cells or their neighbors, and gene editing within a cell. This talk will discuss directed evolution of novel and biomedically relevant AAV variants, as well as the application of gene delivery technologies to investigate cells and stem cells in the nervous system.