The Levine lab has studied mechanisms responsible for switching genes on and off in the early Drosophila embryo for over 30 years. These studies led to the characterization of the eve stripe 2 enhancer, short-range repression, and the regulation of long-range enhancer-promoter interactions. For nearly 20 years they have also studied the gene networks underlying the development of a simple protovertebrate, the sea squirt Ciona intestinalis. These studies led to the identification of rudimentary tissues for key innovations of the vertebrate “new head”, including cranial neural crest, neurogenic placodes, and the second heart field.
The Elf lab has developed new methods for probing transcription factor dynamics at the level of single molecule in living cells. The lab is also developing new methods for tracking individual proteins molecules in living cells at ms time resolution.
The Pelkmans lab operates at the forefront of research in quantitative cell biology, in the study of cell-to-cell variability, as well as in systems approaches based on large- scale genetic perturbations and network biology.
Developmental genetics has furnished the parts list for vertebrate development, but it is not remotely possible to reassemble those parts and predict the outcome. Dr. Siggia wishes to quantify the genetic signals that define morphogenesis.
The Shoichet lab's research program requires a cross disciplinary approach where aspects of engineering, chemistry, and biology are applied to the fields of Regenerative Medicine, Tissue Engineering and Drug Delivery. They have become very interested in drug discovery, drug screening and drug delivery in cancer.
One of the major unsolved mysteries in neuroscience is how synapses are eliminated in the developing and diseased brain. During development synaptic pruning is required for precise brain wiring; however the mechanisms that drive the elimination of specific synapses remain elusive. Emerging evidence implicates resident phagocytes called microglia, and molecules traditionally associated with the immune system.